Educate

yourself and loved ones

If you want to learn more about Pseudobulbar Affect (PBA), look no further. Below you’ll find FAQs and other resources to help you better understand PBA.

Images of people affected by Pseudobulbar Affect (PBA)
Image of a person affected by Pseudobulbar Affect (PBA)

All participants are real patients/caregivers and have been compensated.

All participants are real patients/caregivers and have been compensated.

PBA Frequently Asked Questions

What is Pseudobulbar Affect, or PBA?

Pseudobulbar Affect, or PBA, is a medical condition that causes sudden, frequent, uncontrollable crying and/or laughing episodes that don’t match how the patient is feeling. Many patients report that the crying and/or laughing they experience with PBA feels different than their crying and/or laughing normally does. It can happen in people living with a brain injury or certain neurologic conditions.

What are the primary conditions associated with PBA?

There are six common primary conditions associated with PBA: traumatic brain injury (TBI), stroke, multiple sclerosis (MS), Alzheimer’s disease/dementia, amyotrophic lateral sclerosis (ALS), and Parkinson’s disease. While these are the most common, PBA can also occur with other neurologic conditions.

Can you have PBA if you don’t have a primary condition?

No. PBA cannot occur without first having a neurologic condition or brain injury.

How common is PBA?

It is estimated that 2 million people in the US with neurologic conditions or traumatic brain injury are diagnosed with PBA and up to 7 million who have symptoms suggestive of PBA.*

*When considering patients with any of 6 common neurologic conditions associated with PBA, it is estimated that 37%, or an estimated 7.1 million Americans, have symptoms suggestive of PBA as defined by a CNS-LS (Center for Neurologic Study-Lability Scale) score ≥13 and 9.4% of patients, or an estimated 1.8 million Americans, with CNS-LS scores ≥21. The presence of PBA symptoms was defined as a CNS-LS score ≥13 and a more restrictive definition was also evaluated using CNS-LS ≥21. The CNS-LS was validated as a PBA screening tool in ALS and MS populations. A CNS-LS score ≥13 merits further diagnostic assessment

What is the difference between PBA and depression?

PBA is not depression. It’s important to understand that the two are separate medical conditions. Some people can have both PBA and depression. Both conditions are treatable and should be diagnosed by the patient’s healthcare provider and managed separately. Watch this video to learn more about how PBA and depression are different.

What is the PBA Quiz, also known as the CNS-LS?

The CNS-LS is a self-administered questionnaire designed to be completed by the patient or caregiver. Questions consist of subscales for laughter (4 items) and crying (3 items). Each question is scored on a 5-point scale (1=applies never, 5 = applies most of the time). Total score can range from 7 (no symptoms) to 35 (maximum). A CNS-LS score ≥13 may suggest the presence of signs and symptoms of PBA defined by sudden, frequent, and uncontrollable episodes of laughing and/or crying.

Does the PBA Quiz confirm a diagnosis of PBA?

No, only a doctor can diagnose PBA. The CNS-LS (PBA Quiz) was developed by healthcare professionals to help doctors determine whether a person is having PBA symptoms. It has been validated in ALS (amyotrophic lateral sclerosis) and MS (multiple sclerosis) patient populations.

What kind of doctor should I talk to about PBA?

Any physician who is knowledgeable about the disease can diagnose. However, there are physicians who are more familiar with this area and include:

  • Neurologist
  • Psychiatrist
  • Internist
  • Neuropsychiatrist
  • Physical Medicine & Rehabilitation (aka, Physiatrist)
How do I talk to my doctor about PBA?

Advocating for yourself is important and your doctors, such as your neurologist, primary care physician, or psychiatrist, want to hear from you so they can help. When you talk about your episodes and the impact they have on your life, be specific and don’t hold back. The more details you can provide about your experience and the effects that episodes have on you and your loved ones, the easier it will be for your healthcare provider to understand what you are experiencing. Looking for more ways to prepare for your healthcare appointment? Check out these tips for talking to your doctor.

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Based on your PBA Quiz results, you’re eligible to participate in PBA Nurse Talk.

Get the facts about PBA

Watch the videos below for more information about Pseudobulbar Affect (PBA).

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